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    Recent Posts

    Yansheng Liu is the winner of Early career researcher (ECR) Competition Award at HUPO 2021

    Yansheng Liu is the winner of Early career researcher (ECR) Competition Award at HUPO 2021

    Dr. Yansheng Liu won the 2021 CEP award from Yale SPORE in Lung Cancer

    Dr. Yansheng Liu won the 2021 CEP award from Yale SPORE in Lung Cancer

    The Liu Lab participated the 1ST CASMS Conference

    The Liu Lab participated the 1ST CASMS Conference

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    Tags

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    • DIA
    • must-read
    • proteomics
    • reproducibility
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    Nature Methods features HeLa proteome study from Liu Lab

    Nature Methods features HeLa proteome study from Liu Lab

    “We are proteomic scientists and therefore have a long-term research interest in reproducibility and variability analysis,” says Liu. In 2014, they had the idea of using mass spectrometry to profile the proteomic heterogeneity in cell lines with the “same name.” To this end, they used ‘sequential-window acquisition of all theoretical fragments’ mass spectrometry (SWATH-MS), which can efficiently and reproducibly detect thousands of proteins in cell samples. See full text here
    GenomeWeb features the recent DIA-MS study from Liu Lab

    GenomeWeb features the recent DIA-MS study from Liu Lab

    https://www.genomeweb.com/proteomics-protein-research/yale-team-combines-dia-ms-crispr-study-down-syndrome-protein Using two-hour DIA mass spec runs on a Thermo Fisher Scientific Orbitrap Lumos instrument, the researchers were able to reproducibly quantify roughly 6,200 proteins in HeLa cells with CRISPR-deleted HMGN1, confirming deletion of the target gene and identifying 147 proteins with expression levels that changed significantly following knockout of this gene. Accordin