Proteomics joins the discussion of cell line reproducibility
Liu Y. et al, Nature Biotechnology (2019) Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Abstract: Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Here we investigate the effects of biological variation in HeLa cell lines using a systems-wide approach. We determine the degree of molecular and phenotypic variability across 14 stock HeLa samples from 13 inter