The Liu lab has published a pSILAC-DIA method for measuring protein turnover at EMBO Molecular Systems Biology (IF=9.8).

Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function....

https://www.reviewcommons.org/

Review Commons is a platform for high-quality journal-independent peer-review in the life sciences.

Review Commons provides authors with a Refereed Preprint, which includes the authors’ manuscript, reports from a single round of peer review...

We contributed to a recent study published at Cell leading by CPTAC scientists, who performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Int...

Please see more information here.

https://link.springer.com/article/10.1007/s13361-019-02249-9

The goal of the Emerging Investigators focus is to showcase some of the exciting fundamental and interdisciplinary research that is being performed by a group of researchers wh...

“We are proteomic scientists and therefore have a long-term research interest in reproducibility and variability analysis,” says Liu. In 2014, they had the idea of using mass spectrometry to profile the proteomic heterogeneity in cell lines with the “same name.” To thi...

https://www.genomeweb.com/proteomics-protein-research/yale-team-combines-dia-ms-crispr-study-down-syndrome-protein

Using two-hour DIA mass spec runs on a Thermo Fisher Scientific Orbitrap Lumos instrument, the researchers were able to reproducibly quantify roughly 6,200...

Liu Y. et al, Nature Biotechnology (2019) Multi-omic measurements of heterogeneity in HeLa cells across laboratories.

Abstract:

Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Her...

Mass Spectrometry and Proteomics: Powerful Tools for Cancer Research

                     (Credit to “Peter Baker Photography”)

Advances in mass spectrometry and proteomics

are...

Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a...

The pilot grant committee of U54 Pilot Award of CaSB@ Yale has selected Dr. Yansheng Liu as an 2018 awardee for his pilot study proposal on cancer proteomics entitled "Multilayered Proteomic Quest for Proliferative-to-Aggressive Phenotypic Switch in Melanoma" !