We are grateful and pleased to announce our first NIH R01 with the title "Understanding proteome remodeling in aneuploidy" from NIGMS.

We are pleased to present NAguideR, which is now online at Nucleic Acids Research (IF 11.15). https://doi.org/10.1093/nar/gkaa498.

Mass spectrometry (MS)-based quantitative proteomics experiments frequently generate data with missing values, which may profoundly affect...

Yesterday, Birgit Schilling and Yansheng Liu spoke during our second #Spectronaut 14 user seminar at #ASMS2020 and shared exciting feedback on the new release. To view the recording and learn more about their research, please click on the link below: http://ow.ly/uEy85...

The Liu lab has published a pSILAC-DIA method for measuring protein turnover at EMBO Molecular Systems Biology (IF=9.8).

Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function....

https://www.reviewcommons.org/

Review Commons is a platform for high-quality journal-independent peer-review in the life sciences.

Review Commons provides authors with a Refereed Preprint, which includes the authors’ manuscript, reports from a single round of peer review...

We contributed to a recent study published at Cell leading by CPTAC scientists, who performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Int...

Please see more information here.

https://link.springer.com/article/10.1007/s13361-019-02249-9

The goal of the Emerging Investigators focus is to showcase some of the exciting fundamental and interdisciplinary research that is being performed by a group of researchers wh...

“We are proteomic scientists and therefore have a long-term research interest in reproducibility and variability analysis,” says Liu. In 2014, they had the idea of using mass spectrometry to profile the proteomic heterogeneity in cell lines with the “same name.” To thi...

https://www.genomeweb.com/proteomics-protein-research/yale-team-combines-dia-ms-crispr-study-down-syndrome-protein

Using two-hour DIA mass spec runs on a Thermo Fisher Scientific Orbitrap Lumos instrument, the researchers were able to reproducibly quantify roughly 6,200...

Liu Y. et al, Nature Biotechnology (2019) Multi-omic measurements of heterogeneity in HeLa cells across laboratories.

Abstract:

Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Her...